Invention Grant
US08796279B2 4′-demethylepipodophyllotoxin derivative, preparation method and use thereof
有权
4'-去甲表鬼臼毒素衍生物，其制备方法和用途
- Patent Title: 4′-demethylepipodophyllotoxin derivative, preparation method and use thereof
- Patent Title (中): 4'-去甲表鬼臼毒素衍生物，其制备方法和用途
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Application No.: US14036443Application Date: 2013-09-25
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Publication No.: US08796279B2Publication Date: 2014-08-05
- Inventor: Ya-Jie Tang , Wei Zhao
- Applicant: Hubei University of Technology
- Applicant Address: CN Hubei Province
- Assignee: Hubei University of Technology
- Current Assignee: Hubei University of Technology
- Current Assignee Address: CN Hubei Province
- Agency: Rankin, Hill & Clark LLP
- Priority: CN201010156798 20100423
- Main IPC: A61K31/4965
- IPC: A61K31/4965 ; A01N43/58 ; A01N43/60 ; A61K31/50 ; A61K31/495
Abstract:
A 4′-demethylepipodophyllotoxin derivative of formula (III) having anti-tumor activity is provided. After the activation of hydroxyl in position C4 of 4′-demethylepipodophyllotoxin, tetramethylpyrazine is introduced by transamination to obtain the 4′-demethylepipodophyllotoxin derivative which is preferably used to inhibit gastric cancer line BGC-823.
Public/Granted literature
- US20140024831A1 4'-DEMETHYLEPIPODOPHYLLOTOXIN DERIVATIVE, PREPARATION METHOD AND USE THEREOF Public/Granted day:2014-01-23
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