Invention Grant
US08796287B2 Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
有权
N- [1-（2-乙氧基乙基）-5-（N-乙基-N-甲基氨基）-7-（4-甲基吡啶-2-基 - 氨基）-1H-吡唑并[4,3-d ]嘧啶-3-羰基]甲磺酰胺
![Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide](/docs/US/2014-08-05/US08796287B2/abs.jpg.600x600.jpg)
- Patent Title: Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
- Patent Title (中): N- [1-（2-乙氧基乙基）-5-（N-乙基-N-甲基氨基）-7-（4-甲基吡啶-2-基 - 氨基）-1H-吡唑并[4,3-d ]嘧啶-3-羰基]甲磺酰胺
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Application No.: US13457886Application Date: 2012-04-27
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Publication No.: US08796287B2Publication Date: 2014-08-05
- Inventor: David Andrew Entwistle , Peter Vallance Marshall , Stefan Colin John Taylor
- Applicant: David Andrew Entwistle , Peter Vallance Marshall , Stefan Colin John Taylor
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agent James T. Wasicak
- Main IPC: A01N43/90
- IPC: A01N43/90 ; A61K31/519 ; C07D487/00
![Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide](/abs-image/US/2014/08/05/US08796287B2/abs.jpg.150x150.jpg)
Abstract:
The invention comprises (1) anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide, (2) pharmaceutical compositions comprising at least one such form, (3) methods for the treatment of a phosphodiesterase-5-mediated condition using at least one such form, and (4) methods for preparing such forms. The compound N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide has the following structure (I).
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