Invention Grant
US08796298B2 Combination of a B-Raf inhibitor: N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1- dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide and the Akt inhibitor: N-{ (1S)-2-amino-1-[(3- fluorophenyl)methyl]ethyl}-5-chIoro-4-(4-chIoro- 1 -methyl- 1 H-pyrazol-5-yl)-2-10 thiophenecarboxamide useful in the treatment of cancer
有权
B-Raf抑制剂的组合：N- {3- [5-（2-氨基-4-嘧啶基）-2-（1,1-二甲基乙基）-1,3-噻唑-4-基] -2-氟苯基 } -2,6-二氟苯磺酰胺和Akt抑制剂：N - {（1S）-2-氨基-1 - [（3-氟苯基）甲基]乙基} -5-氯-4-（4-氯-1-甲基 -1H-吡唑-5-基）-2-10噻吩甲酰胺可用于治疗癌症
![Combination of a B-Raf inhibitor: N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1- dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide and the Akt inhibitor: N-{ (1S)-2-amino-1-[(3- fluorophenyl)methyl]ethyl}-5-chIoro-4-(4-chIoro- 1 -methyl- 1 H-pyrazol-5-yl)-2-10 thiophenecarboxamide useful in the treatment of cancer](/docs/US/2014-08-05/US08796298B2/abs.jpg.600x600.jpg)
- Patent Title: Combination of a B-Raf inhibitor: N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1- dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide and the Akt inhibitor: N-{ (1S)-2-amino-1-[(3- fluorophenyl)methyl]ethyl}-5-chIoro-4-(4-chIoro- 1 -methyl- 1 H-pyrazol-5-yl)-2-10 thiophenecarboxamide useful in the treatment of cancer
- Patent Title (中): B-Raf抑制剂的组合：N- {3- [5-（2-氨基-4-嘧啶基）-2-（1,1-二甲基乙基）-1,3-噻唑-4-基] -2-氟苯基 } -2,6-二氟苯磺酰胺和Akt抑制剂：N - {（1S）-2-氨基-1 - [（3-氟苯基）甲基]乙基} -5-氯-4-（4-氯-1-甲基 -1H-吡唑-5-基）-2-10噻吩甲酰胺可用于治疗癌症
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Application No.: US13500698Application Date: 2010-10-08
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Publication No.: US08796298B2Publication Date: 2014-08-05
- Inventor: Melissa Dumble , Tona Gilmer , Rakesh Kumar , Peter F. Lebowitz , Shannon Renae Morris , Sylvie Laquerre
- Applicant: Melissa Dumble , Tona Gilmer , Rakesh Kumar , Peter F. Lebowitz , Shannon Renae Morris , Sylvie Laquerre
- Applicant Address: US DE Wilmington
- Assignee: GlaxoSmithKline LLC
- Current Assignee: GlaxoSmithKline LLC
- Current Assignee Address: US DE Wilmington
- Agent Wayne J. Dustman; Edward R. Gimmi
- International Application: PCT/US2010/051909 WO 20101008
- International Announcement: WO2011/044415 WO 20110414
- Main IPC: A61K31/506
- IPC: A61K31/506 ; A61K35/00 ; A61P35/02
![Combination of a B-Raf inhibitor: N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1- dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide and the Akt inhibitor: N-{ (1S)-2-amino-1-[(3- fluorophenyl)methyl]ethyl}-5-chIoro-4-(4-chIoro- 1 -methyl- 1 H-pyrazol-5-yl)-2-10 thiophenecarboxamide useful in the treatment of cancer](/abs-image/US/2014/08/05/US08796298B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, and N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.
Public/Granted literature
- US20120202835A1 COMBINATION Public/Granted day:2012-08-09
Information query
IPC分类:
