Invention Grant
- Patent Title: 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
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Application No.: US12529568Application Date: 2008-03-07
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Publication No.: US08796311B2Publication Date: 2014-08-05
- Inventor: Jose Maria Cid-Nunez , Andres Avelino Trabanco-Suarez , Gregor James MacDonald , Guillaume Albert Jacques Duvey
- Applicant: Jose Maria Cid-Nunez , Andres Avelino Trabanco-Suarez , Gregor James MacDonald , Guillaume Albert Jacques Duvey
- Applicant Address: US NJ Titusville CH Geneva
- Assignee: Janssen Pharmaceuticals, Inc.,Addex Pharma, SA
- Current Assignee: Janssen Pharmaceuticals, Inc.,Addex Pharma, SA
- Current Assignee Address: US NJ Titusville CH Geneva
- Agency: Baker & Hostetler LLP
- Priority: EP07103654 20070307; WOPCT/EP07/052442 20070315; EP07116403 20070914
- International Application: PCT/EP2008/052768 WO 20080307
- International Announcement: WO2008/107481 WO 20080912
- Main IPC: C07D405/12
- IPC: C07D405/12 ; A61K31/4433

Abstract:
The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) including any stereochemically isomeric form thereof, or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic glutamate receptors subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and such compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.
Public/Granted literature
- US08906939B2 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives Public/Granted day:2014-12-09
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