Invention Grant
- Patent Title: Human epidermal growth factor receptor variant lacking an exon
- Patent Title (中): 人表皮生长因子受体变体缺乏外显子
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Application No.: US13879538Application Date: 2011-10-24
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Publication No.: US08796421B2Publication Date: 2014-08-05
- Inventor: Zonghai Li , Min Zhou , Hai Wang , Bizhi Shi , Shengli Yang , Hongyang Wang , Jianren Gu
- Applicant: Zonghai Li , Min Zhou , Hai Wang , Bizhi Shi , Shengli Yang , Hongyang Wang , Jianren Gu
- Applicant Address: CN Shanghai
- Assignee: Shanghai Cancer Institute
- Current Assignee: Shanghai Cancer Institute
- Current Assignee Address: CN Shanghai
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: CN201010510056 20101015
- International Application: PCT/CN2011/081162 WO 20111024
- International Announcement: WO2012/048667 WO 20120419
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K14/00 ; C07K17/00
Abstract:
The present invention provides an epidermal growth factor receptor variant-de4 EGFR protein. The variant lacks the fourth exon of the epidermal growth factor receptor, and promotes tumor cell invasion/metastasis. The present invention also provides an encoding gene for the variant and a method of producing the variant by means of recombination technology.
Public/Granted literature
- US20130236465A1 EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT LACKING EXON Public/Granted day:2013-09-12
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