Invention Grant
- Patent Title: Compounds for inhibiting KSP kinesin activity
- Patent Title (中): 用于抑制KSP驱动蛋白活性的化合物
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Application No.: US12738537Application Date: 2008-10-16
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Publication No.: US08796460B2Publication Date: 2014-08-05
- Inventor: M. Arshad Siddiqui , Chaoyang Dai , Umar Faruk Mansoor , Liping Yang , Lalalnthi Dilrukshi Vitharana , Angie R. Angeles
- Applicant: M. Arshad Siddiqui , Chaoyang Dai , Umar Faruk Mansoor , Liping Yang , Lalalnthi Dilrukshi Vitharana , Angie R. Angeles
- Applicant Address: US NY Rahway
- Assignee: Mercky Sharp & Dohme Corp.
- Current Assignee: Mercky Sharp & Dohme Corp.
- Current Assignee Address: US NY Rahway
- Agent Li Su; Laura Ginkel
- International Application: PCT/US2008/080164 WO 20081016
- International Announcement: WO2009/052288 WO 20090423
- Main IPC: C07D211/26
- IPC: C07D211/26 ; A61K31/397 ; C07D211/14 ; C07D471/04
Abstract:
The present invention relates to compounds of Formula (I), below, (wherein X, R1, R2, R3, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity. Formula I
Public/Granted literature
- US20110123435A1 COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY Public/Granted day:2011-05-26
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