An integrated circuit may have rows and columns of imaging pixel arrays. Row driver circuitry and column readout circuitry may be shared between the imaging pixel arrays. Control circuit blocks may bypass inactive pixel arrays and may shift signals between different signal paths on the integrated circuit. The control circuit blocks may include synchronizing circuitry for deskewing control signals and buffer circuitry for regenerating weak signals as they are distributed across the integrated circuit. An array of lenses may be associated with the integrated circuit. The spacing between imaging pixel arrays may differ at different parts of the integrated circuit. Images from multiple image sensor pixel arrays may be combined to form a single digital image. Image sensors may be provided with unique lenses, different color responses, different image pixels, different image pixel patterns, and other differences. Reference pixels may be interposed in the gaps between image sensor arrays.