An encryption endpoint (EE) receives, via a storage I/O stack (having a key controller module (KCM)), encryption metadata identifying an encryption key and a set of region entries. Each region entry includes an identification of a region within a storage device subject to encryption with the encryption key and an identification of a correlation between the region and a corresponding region on a logical volume (LV) managed by the KCM. The EE receives, via the stack, a storage command to process a block having a first address on the storage device. It corresponds to a second address located within the corresponding region of the LV. The EE determines the second address within the LV and then cryptographically processes the block using an address-dependent cryptographic algorithm and (a) data of the block, (b) the determined second address, and (c) the encryption key.