Systems and methods for monitoring the acoustic coupling of medical devices is disclosed. An illustrative system for monitoring the acoustic coupling of an acoustic transducer attached to a patient's body includes a signal generator adapted to supply an electrical signal to the transducer, a circuit configured to measure at least one electrical parameter of the transducer, and a processor adapted to evaluate the degree of acoustic coupling of the transducer to the body based on the measured electrical signal. The processor can measure the frequency response of the acoustic transducer to the electrical signal, a time domain response of the acoustic transducer to the electrical signal, or a combination of both.