Invention Grant
- Patent Title: Anti-RSPO1 antibodies
- Patent Title (中): 抗RSPO1抗体
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Application No.: US13549050Application Date: 2012-07-13
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Publication No.: US08802097B2Publication Date: 2014-08-12
- Inventor: Austin L. Gurney , Fumiko Takada Axelrod , Timothy Charles Hoey , Cecile Chartier-Courtaud
- Applicant: Austin L. Gurney , Fumiko Takada Axelrod , Timothy Charles Hoey , Cecile Chartier-Courtaud
- Applicant Address: US CA Redwood City
- Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; C07K16/00 ; C07K16/18
Abstract:
The present invention relates to RSPO-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO proteins and modulate β-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO proteins, such as antibodies that specifically bind RSPO1, RSPO2, and/or RSPO3 and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
Public/Granted literature
- US20130095116A1 RSPO Binding Agents and Uses Thereof Public/Granted day:2013-04-18
Information query
