Invention Grant
US08802648B2 Repressor on IFN-λ promoter and siRNA against ZEB1 and BLIMP-1 to increase IFN-λ gene activity
有权
抑制IFN-λ启动子和针对ZEB1和BLIMP-1的siRNA以增加IFN-λ基因活性
- Patent Title: Repressor on IFN-λ promoter and siRNA against ZEB1 and BLIMP-1 to increase IFN-λ gene activity
- Patent Title (中): 抑制IFN-λ启动子和针对ZEB1和BLIMP-1的siRNA以增加IFN-λ基因活性
-
Application No.: US13693383Application Date: 2012-12-04
-
Publication No.: US08802648B2Publication Date: 2014-08-12
- Inventor: Grant Gallagher , Rachel Siegel , Joyce Eskdale
- Applicant: Medical Diagnostic Laboratories, LLC
- Agent Siu K. Lo
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/02 ; C07H21/04 ; C12N15/113 ; C12N15/11 ; A61K31/713 ; C12Q1/68
Abstract:
The present invention is directed to the identification of a novel repressor located between ˜1.2 kb to ˜1.6 kb from the translation start site of the IFN-λ1 promoter. The present invention provides a method of using siRNAs against ZEB1 (binds to the repressor region) and BLIMP-1 (binds outside the repressor region) and increases the promoter activity of IFN-λ1 (i.e., increases the production of IFN-λ1 protein). siRNAs against ZEB1 mRNA or BLIMP-1 mRNA increase IFN-λ1 gene activity. There is provided a therapeutic application of siRNAs against ZEB1 and BLIMP-1 mRNAs in treating a mammal (including a human) by increasing the production of IFN-λ1 protein that promotes an anti-viral response as well as treats asthma diseases.
Public/Granted literature
Information query
