Invention Grant
- Patent Title: Adenine derivatives
- Patent Title (中): 腺嘌呤衍生物
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Application No.: US14032555Application Date: 2013-09-20
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Publication No.: US08802684B2Publication Date: 2014-08-12
- Inventor: Helene Bazin-Lee , Diane Mary Coe , Charlotte Jane Mitchell , Stephen Allan Smith
- Applicant: GlaxoSmithKline LLC
- Applicant Address: US PA Philadelphia
- Assignee: GlaxoSmithKline LLC
- Current Assignee: GlaxoSmithKline LLC
- Current Assignee Address: US PA Philadelphia
- Agent Kathryn L. Coulter
- Main IPC: C07D473/18
- IPC: C07D473/18

Abstract:
Compounds of formula (I): wherein R1 is C1-6alkylamino, or C1-6alkoxy; R2 is a group having the structure: n is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the —(CH2)n— moiety at any carbon atom of the heterocycle; R3 is hydrogen, C1-8alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
Public/Granted literature
- US20140024664A1 NOVEL ADENINE DERIVATIVES Public/Granted day:2014-01-23
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