Invention Grant
- Patent Title: Connective tissue growth factor antisense oligonucleotides
- Patent Title (中): 结缔组织生长因子反义寡核苷酸
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Application No.: US13546799Application Date: 2012-07-11
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Publication No.: US08802839B2Publication Date: 2014-08-12
- Inventor: Mark D. Sternlicht , Todd W. Seeley
- Applicant: Mark D. Sternlicht , Todd W. Seeley
- Applicant Address: US CA San Francisco
- Assignee: FibroGen, Inc.
- Current Assignee: FibroGen, Inc.
- Current Assignee Address: US CA San Francisco
- Agent Leanne C. Price, Esq.; Paul Borchardt
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/113
Abstract:
The present invention relates to antisense oligonucleotides that target human CTGF mRNA and inhibit CTGF mRNA expression. Additionally, regions of human CTGF mRNA that are exceptionally sensitive to antisense inhibition are disclosed. Pharmaceutical compositions comprising the antisense oligonucleotides are further disclosed. These compositions are useful for treating disorders and conditions that are associated with or influenced by CTGF expression.
Public/Granted literature
- US20130178510A1 CONNECTIVE TISSUE GROWTH FACTOR ANTISENSE OLIGONUCLEOTIDES Public/Granted day:2013-07-11
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