A configurable multimode despreader for spread spectrum applications is disclosed herein. The despreader includes a plurality of data lines, at least one selective coupler coupled to the plurality of data lines, at least one multiplier coupled to the selective coupler, and a code input line coupled to the multiplier. The selective coupler selectively couples one of the plurality of data lines with the multiplier per any one of a plurality of despreading protocols. The multiplier then multiplies a desired input data type received from the selective coupler with a despreading code chip received from the code input line to produce an observation. The programmable multimode despreader supports variable code and data modulation schemes and variable spreading factors.