A calibration system for calibrating wireless circuitry in an electronic device is provided. The test system may include test equipment, a computer, and a device under test (DUT). The test equipment may measure the output power of the DUT. The DUT may include power amplifier circuitry that is provided with a power supply voltage supplied by power supply circuitry. A list mode sequence of commands may be provided to the DUT and the test equipment to calibrate the power amplifier circuitry. The list of commands may be processed by the DUT to produce radio-frequency signals. The list of commands may be simultaneously processed by the test equipment to perform measurements on the radio-frequency signals. The computer may retrieve measurement data from the test equipment after testing is complete. The computer may subsequently determine calibrated control settings for the DUT that reduce power consumption while ensuring satisfactory adjacent channel leakage performance.