A client computing system identifies a start of a multi-operational transaction pertaining to access of data stored in caches being managed by nodes residing in Java Virtual Machines in an in-memory data grid. The client computing system stores transaction context data indicating the start of the multi-operational transaction and identifies an application request to perform an operation pertaining to the multi-operational transaction. The application request is from an application that resides outside of the Java Virtual Machines of the nodes. The client computing system determines the transaction context of the operation based on the transaction context data and sends an operation request over a network to a managing node in the in-memory data grid to manage the multi-operational transaction. The operation request includes header data based on the transaction context data.