System and method for an information security device with a compact flash (CF) interface are disclosed. The information security device determines an object being operated according to an instruction sent by a host using a card reading apparatus, and performs a flash memory operation or an information security operation. The determining by the information security device of the object being operated by the host includes the control chip of the information security device determining whether the object being operated by the host with the card reading apparatus is a real section or a virtual section inside the device, wherein the real section refers to the section in the flash module of the information security device, and the virtual section is predefined in the information security chip in the information security device.