A Not and Flash (Nandflash) controller and a data transmission method with the Nandflash controller are provided. The Nandflash controller includes a parameter configuration device, configured to receive an operation command from outside, wherein the operation command indicates a current transmission type, number of times needed for transmitting data, size of which is same as that of a buffer in the Nandflash, and command parameters used by each execution; a transmission controlling device, configured to transmit data of a precoded size to/from the Nandflash during each data transmission according to the current transmission type and the command parameters used by this execution the number of times indicated by the operation command. The controller and method advantageously avoid configuring a command for the next operation each time the data of the precoded size is transmitted, save time and clock resources, and greatly improves transmission efficiency.