A tactical flotation safety system having a tactical flotation safety vest attachment removably attached to a tactical vest. The tactical flotation safety vest attachment has two side panels adjustably attached at the back and which are secured at the front and back of the tactical vest with cover panels. The two side panels include inner flaps and outer flaps enclosing inflation bladders and inflation mechanisms. The inflation mechanisms are secured to the interiors of the side panels and connected to exterior handles. When necessary, a user may deploy the inflation bladders by pulling on the handles to activate a pressurized gas source, such as liquid carbon dioxide cartridges of the inflation mechanism thereby inflating the bladders to provide buoyancy to the user.