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US08808692B2 Compositions comprising immunoreactive reagents and saponins, and methods of use thereof 有权
包含免疫反应性试剂和皂苷的组合物及其使用方法

Compositions comprising immunoreactive reagents and saponins, and methods of use thereof
Abstract:
The present invention relates to pharmaceutical compositions that are useful for the prevention and treatment of infectious diseases, primary and metastatic neoplastic diseases (i.e., cancer), neurodegenerative or amyloid diseases, or any other disease wherein the treatment of such disease would be improved by an enhanced immune response, and methods of formulating the compositions. The compositions comprise an immunoreactive reagent (i.e., an antigen binding protein comprising an antigen binding region and a region or regions of an antibody that mediate antibody dependent immunological processes) and a saponin. The present invention also relates to methods of using the compositions of the invention for the prevention and/or treatment of infectious diseases, primary and metastatic neoplastic diseases (i.e., cancer), neurodegenerative or amyloid diseases, or any other disease wherein the treatment of such disease would be improved by an enhanced immune response.
Abstract(Chinese):

本发明涉及可用于预防和治疗感染性疾病，原发性和转移性肿瘤性疾病（即癌症），神经变性或淀粉样蛋白病或任何其它疾病的药物组合物，其中该疾病的治疗将通过 增强的免疫应答和配制组合物的方法。 组合物包含免疫反应性试剂（即，包含抗原结合区域的抗原结合蛋白和介导抗体依赖性免疫学过程的抗体的区域或区域）和皂苷。 本发明还涉及使用本发明组合物预防和/或治疗感染性疾病，原发性和转移性肿瘤性疾病（即癌症），神经退行性或淀粉样蛋白病或其它疾病的方法。 疾病将通过增强的免疫应答而改善。

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