Invention Grant
US08808703B2 Compounds (cystein based lipopeptides) and compositions as TLR2 agonists used for treating infections, inflammations, respiratory diseases etc
有权
化合物（基于半胱氨酸的脂肽）和用作治疗感染，炎症，呼吸系统疾病等的TLR2激动剂的组合物
- Patent Title: Compounds (cystein based lipopeptides) and compositions as TLR2 agonists used for treating infections, inflammations, respiratory diseases etc
- Patent Title (中): 化合物（基于半胱氨酸的脂肽）和用作治疗感染，炎症，呼吸系统疾病等的TLR2激动剂的组合物
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Application No.: US13636328Application Date: 2011-03-23
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Publication No.: US08808703B2Publication Date: 2014-08-19
- Inventor: Tom Yao-Hsiang Wu , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan
- Applicant: Tom Yao-Hsiang Wu , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan
- Agency: Genomics Institute of the Novartis Research Foundation
- Agent Daniel E. Raymond
- International Application: PCT/US2011/029661 WO 20110323
- International Announcement: WO2011/119759 WO 20110929
- Main IPC: A61K49/00
- IPC: A61K49/00 ; A61K39/385 ; A61K39/12 ; A61K39/02 ; A61K45/00
Abstract:
The invention provides a novel class of compounds viz. generally lipopeptides like Pam3CSK4, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 2. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness a vaccine.
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