Invention Grant
US08808768B2 Development of biochemically standardized extracts from fresh rhizomes of turmeric (Curcuma longa) for treatment of diseases caused by hyperuricemia 有权
开发姜黄(姜黄)新鲜根茎生物化学标准化提取物,用于治疗由高尿酸血症引起的疾病

  • Patent Title: Development of biochemically standardized extracts from fresh rhizomes of turmeric (Curcuma longa) for treatment of diseases caused by hyperuricemia
  • Patent Title (中): 开发姜黄(姜黄)新鲜根茎生物化学标准化提取物,用于治疗由高尿酸血症引起的疾病
  • Application No.: US12460474
    Application Date: 2009-07-20
  • Publication No.: US08808768B2
    Publication Date: 2014-08-19
  • Inventor: Kailash Chandra Agarwal
  • Applicant: Kailash Chandra Agarwal
  • Main IPC: A61K36/9066
  • IPC: A61K36/9066
Development of biochemically standardized extracts from fresh rhizomes of turmeric (Curcuma longa) for treatment of diseases caused by hyperuricemia
Abstract:
The present invention demonstrates the ethanol extracts of fresh rhizome of turmeric (Curcuma longa) strongly inhibit xanthine oxidase, a key biological enzyme responsible for the production of uric acid and superoxide radicals. The dose-response data demonstrate the turmeric extracts prepared with 40% and 50% ethanol are much stronger inhibitors of xanthine oxidase than curcumin. Based on the enzyme-inhibitory data (IC50 values), a biochemical method is developed to standardize turmeric extracts/products as Enzyme-Inhibitory Units (EIU), which has many commercial and biological applications, including, identification and development of pharmacologically effective turmeric products; use of turmeric extracts/products with EIU values >50 per mg to prevent the production of harmful uric acid and superoxides in diseases caused by hyperuricemia and gout; determination of the stability (shelf-life) of turmeric products stored at the retail stores by comparing their EIU values.
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