Invention Grant
US08808980B2 Stabilized open form transglutaminase as a diagnostic indictor for autoimmune diseases
有权
稳定的开放型转谷氨酰胺酶作为自身免疫性疾病的诊断指标
- Patent Title: Stabilized open form transglutaminase as a diagnostic indictor for autoimmune diseases
- Patent Title (中): 稳定的开放型转谷氨酰胺酶作为自身免疫性疾病的诊断指标
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Application No.: US13509225Application Date: 2010-11-11
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Publication No.: US08808980B2Publication Date: 2014-08-19
- Inventor: Martin Hils , Ralf Pasternack , Johannes Weber
- Applicant: Martin Hils , Ralf Pasternack , Johannes Weber
- Applicant Address: DE Darmstadt
- Assignee: Zedira GmbH
- Current Assignee: Zedira GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Meyertons, Hood, Kivlin, Kowert & Goetzel, P.C.
- Agent Eric B. Meyertons
- Priority: EP09014100 20091111; EP10007682 20100623
- International Application: PCT/EP2010/006983 WO 20101111
- International Announcement: WO2011/057826 WO 20110519
- Main IPC: C12Q1/00
- IPC: C12Q1/00
Abstract:
The present invention relates to the diagnosis of disorders or dysfunctions characterized by autoimmune responses to the enzyme class of transglutaminases. The present invention provides a novel open structure of the transglutaminases in a stabilized form which renders new epitopes accessible for antibody-binding.
Public/Granted literature
- US20120315262A1 STABILIZED OPEN FORM TRANSGLUTAMINASE AS A DIAGNOSTIC INDICTOR FOR AUTOIMMUNE DISEASES Public/Granted day:2012-12-13
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