Invention Grant
US08809024B2 Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor
有权
二肽基肽酶IV抑制剂及其中间体的制备方法
- Patent Title: Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor
- Patent Title (中): 二肽基肽酶IV抑制剂及其中间体的制备方法
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Application No.: US13734650Application Date: 2013-01-04
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Publication No.: US08809024B2Publication Date: 2014-08-19
- Inventor: Michael Politino , Matthew M. Cadin , Jason G. Chen
- Applicant: AstraZeneca AB
- Applicant Address: SE Sodertalje
- Assignee: AstraZeneca AB
- Current Assignee: AstraZeneca AB
- Current Assignee Address: SE Sodertalje
- Agent Terence J. Bogie
- Main IPC: C12P13/00
- IPC: C12P13/00 ; A61K31/40 ; C12P1/00 ; C12N9/06 ; C07C13/28
Abstract:
A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine.
Public/Granted literature
- US20130204012A1 Process For Preparing Dipeptidyl Peptidase IV Inhibitors And Intermediates Therefor Public/Granted day:2013-08-08
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