Invention Grant
- Patent Title: Method for producing peptide
- Patent Title (中): 生产肽的方法
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Application No.: US12671238Application Date: 2008-07-30
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Publication No.: US08809258B2Publication Date: 2014-08-19
- Inventor: Yasuhiro Kajihara , Izumi Sakamoto , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai
- Applicant: Yasuhiro Kajihara , Izumi Sakamoto , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai
- Applicant Address: JP Kyoto
- Assignee: Glytech, Inc.
- Current Assignee: Glytech, Inc.
- Current Assignee Address: JP Kyoto
- Agency: Brinks Gilson & Lione
- Priority: JP2007-199372 20070731
- International Application: PCT/JP2008/063659 WO 20080730
- International Announcement: WO2009/017154 WO 20090205
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K1/04 ; C07K14/00

Abstract:
The present invention provides a method for producing a peptide, characterized in that it comprises converting an —SH group of a peptide comprising an amino acid residue having the —SH group to an —OH group, wherein said method comprises the following steps (a) to (c): (a) allowing an —SH group in a peptide to react with a methylating agent to convert the —SH group to an -SMe group; (b) allowing the -SMe group obtained in the step (a) to react with a cyanizing agent to produce a reaction intermediate; and (c) converting the reaction intermediate obtained in the step (b) to a peptide comprising an amino acid residue having an —OH group under more basic conditions than the conditions in the step (b).
Public/Granted literature
- US20110172392A1 METHOD FOR PRODUCING PEPTIDE Public/Granted day:2011-07-14
Information query
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