Invention Grant
- Patent Title: Compositions and methods for altering Wnt autocrine signaling
- Patent Title (中): 用于改变Wnt自分泌信号的组合物和方法
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Application No.: US11719327Application Date: 2005-11-15
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Publication No.: US08809287B2Publication Date: 2014-08-19
- Inventor: Anna Bafico , Stuart Aaronson
- Applicant: Anna Bafico , Stuart Aaronson
- Applicant Address: US NY New York
- Assignee: Icahn School of Medicine at Mount Sinai
- Current Assignee: Icahn School of Medicine at Mount Sinai
- Current Assignee Address: US NY New York
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2005/041531 WO 20051115
- International Announcement: WO2006/055635 WO 20060526
- Main IPC: C12N15/11
- IPC: C12N15/11 ; A61K48/00 ; A61K38/17 ; A61K45/06
Abstract:
The present invention relates to compounds and methods for treating cancers in which the autocrine Wnt canonical signaling pathway is activated. In particular, there is provided a method for inhibiting growth of a tumor cell or sensitizing a cancer cell to treatment by contacting such a tumor cell with a compound that alters Wnt signaling. The compound that alters Wnt signaling can be a Wnt antagonist, a Wnt receptor antagonist, or a combination thereof.
Public/Granted literature
- US20090163407A1 COMPOSITIONS AND METHODS FOR ALTERING WNT AUTOCRINE SIGNALING Public/Granted day:2009-06-25
Information query
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