Invention Grant
- Patent Title: Inhibitors of NEDD8-activating enzyme
- Patent Title (中): NEDD8活化酶抑制剂
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Application No.: US13592389Application Date: 2012-08-23
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Publication No.: US08809356B2Publication Date: 2014-08-19
- Inventor: Ashley Sue McCarron , Todd B. Sells , Matthew Stirling , Stephen G. Stroud
- Applicant: Ashley Sue McCarron , Todd B. Sells , Matthew Stirling , Stephen G. Stroud
- Applicant Address: US MA Cambridge
- Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Main IPC: C07D239/47
- IPC: C07D239/47

Abstract:
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.
Public/Granted literature
- US20130150388A1 INHIBITORS OF NEDD8-ACTIVATING ENZYME Public/Granted day:2013-06-13
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