Invention Grant
US08809402B2 Oxazolone and pyrrolidinone-substituted biphenyls as P2X3 and P2X2/3 antagonists
有权
恶唑酮和吡咯烷酮取代的联苯作为P2X3和P2X2 / 3拮抗剂
- Patent Title: Oxazolone and pyrrolidinone-substituted biphenyls as P2X3 and P2X2/3 antagonists
- Patent Title (中): 恶唑酮和吡咯烷酮取代的联苯作为P2X3和P2X2 / 3拮抗剂
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Application No.: US13314529Application Date: 2011-12-08
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Publication No.: US08809402B2Publication Date: 2014-08-19
- Inventor: Li Chen , Michael Patrick Dillon , Lichun Feng , Minmin Yang
- Applicant: Li Chen , Michael Patrick Dillon , Lichun Feng , Minmin Yang
- Applicant Address: US CA Palo Alto
- Assignee: Roche Palo Alto LLC
- Current Assignee: Roche Palo Alto LLC
- Current Assignee Address: US CA Palo Alto
- Agent Robert C. Hall
- Main IPC: A61K31/015
- IPC: A61K31/015 ; C07D473/00 ; C07D207/27 ; C07D413/10 ; C07D263/20 ; C07D413/14 ; C07D401/14 ; C07D413/12 ; C07D233/32
Abstract:
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
Public/Granted literature
- US20120083500A1 OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X 2/3 ANTAGONISTS Public/Granted day:2012-04-05
Information query
