Invention Grant
US08809495B2 Peptides imparting cell permeability to lipid membrane structure and/or enhancing cell permeability of lipid membrane structure, and lipid membrane structure comprising lipid bound to such peptide as constituent lipid and having cell permeability or showing enhanced cell permeability
有权
赋予细胞对脂质膜结构的渗透性和/或增强脂质膜结构的细胞渗透性的肽，以及脂质膜结构，其包含结合到诸如构成脂质的肽和具有细胞渗透性或显示增强的细胞渗透性
- Patent Title: Peptides imparting cell permeability to lipid membrane structure and/or enhancing cell permeability of lipid membrane structure, and lipid membrane structure comprising lipid bound to such peptide as constituent lipid and having cell permeability or showing enhanced cell permeability
- Patent Title (中): 赋予细胞对脂质膜结构的渗透性和/或增强脂质膜结构的细胞渗透性的肽，以及脂质膜结构，其包含结合到诸如构成脂质的肽和具有细胞渗透性或显示增强的细胞渗透性
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Application No.: US13515970Application Date: 2010-12-14
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Publication No.: US08809495B2Publication Date: 2014-08-19
- Inventor: Hideyoshi Harashima , Takahiro Fujiwara , Hidetaka Akita
- Applicant: Hideyoshi Harashima , Takahiro Fujiwara , Hidetaka Akita
- Applicant Address: JP Sapporo-Shi
- Assignee: National University Corporation Hokkaido University
- Current Assignee: National University Corporation Hokkaido University
- Current Assignee Address: JP Sapporo-Shi
- Agency: RatnerPrestia
- Priority: JP2009-283091 20091214
- International Application: PCT/JP2010/072485 WO 20101214
- International Announcement: WO2011/074578 WO 20110623
- Main IPC: C07K7/06
- IPC: C07K7/06 ; A61K47/42 ; A61K9/127 ; C07K14/47 ; A61K38/00 ; A61K39/00
Abstract:
Provided are peptides imparting cell permeability to a lipid membrane structure and/or enhancing the cell permeability of a lipid membrane structure, and a lipid membrane structure which comprises, as a constituent lipid, a lipid bound to such a peptide and has cell permeability or shows enhanced cell permeability. The amino acid sequences of the peptides imparting cell permeability to a lipid membrane structure and/or enhancing the cell permeability of a lipid membrane structure are represented by: LX1X2X1X1X1L, LLX2X1X1X1L and LX1X2X1X1L (wherein L represents a leucine residue; X1 represents a polar amino acid residue; and X2 represents a polar, non-charged and branched chain amino acid residue).
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