Invention Grant
US08809506B2 Antibodies and vaccines for use in therapeutic and diagnostic methods for α-synuclein-related disorders
有权
用于α-突触核蛋白相关疾病的治疗和诊断方法的抗体和疫苗
- Patent Title: Antibodies and vaccines for use in therapeutic and diagnostic methods for α-synuclein-related disorders
- Patent Title (中): 用于α-突触核蛋白相关疾病的治疗和诊断方法的抗体和疫苗
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Application No.: US12990226Application Date: 2009-04-28
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Publication No.: US08809506B2Publication Date: 2014-08-19
- Inventor: Lars Lannfelt , Joakim Bergström , Martin Ingelsson , Pär Gellerfors
- Applicant: Lars Lannfelt , Joakim Bergström , Martin Ingelsson , Pär Gellerfors
- Applicant Address: SE Stockholm
- Assignee: BioArctic Neuroscience AB
- Current Assignee: BioArctic Neuroscience AB
- Current Assignee Address: SE Stockholm
- Agency: Porter Wright Morris & Arthur LLP
- International Application: PCT/IB2009/051731 WO 20090428
- International Announcement: WO2009/133521 WO 20091105
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18 ; G01N33/567 ; A61K38/17 ; G01N33/68
Abstract:
A vaccine for delaying an onset of or for treatment of an α-synuclein-related disorder in an individual comprises a therapeutically effective amount of isolated stabilized soluble α-synuclein oligomer having a lower formation rate to a non-soluble aggregated form than a non-stabilized oligomer of the α-synuclein. An antibody for delaying an onset of or for treatment of an α-synuclein-related disorder in an individual binds soluble α-synuclein. Methods for delaying an onset of for treatment or for prevention of an α-synuclein-related disorder employ the vaccine or antibody. Methods of detecting α-synuclein oligomers employ the antibody.
Public/Granted literature
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