Invention Grant
- Patent Title: Process for the manufacture of TMHQ
- Patent Title (中): 制造TMHQ的过程
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Application No.: US13817012Application Date: 2011-08-25
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Publication No.: US08809591B2Publication Date: 2014-08-19
- Inventor: Werner Bonrath , Thomas Netscher , Jan Schütz , Bettina Wüstenberg
- Applicant: Werner Bonrath , Thomas Netscher , Jan Schütz , Bettina Wüstenberg
- Applicant Address: NL Heerlen
- Assignee: DSM IP Assets B.V.
- Current Assignee: DSM IP Assets B.V.
- Current Assignee Address: NL Heerlen
- Agency: Nixon & Vanderhye P.C.
- Priority: EP10174083 20100826
- International Application: PCT/EP2011/064623 WO 20110825
- International Announcement: WO2012/025587 WO 20120301
- Main IPC: C07C45/62
- IPC: C07C45/62 ; C07C45/65 ; C07C215/50 ; C07C225/00 ; C07D295/116 ; C07D311/04

Abstract:
The present invention is directed to a process for the manufacture of 2,3,5-trimethyl-hydro-p-benzoquinone comprising the following steps: a) hydrogenating 2,6-dimethyl-p-benzoquinone with hydrogen in the presence of a hydrogenation catalyst in an organic solvent to obtain 2,6-dimethyl-hydro-p-benzoquinone; b) reacting 2,6-dimethyl-hydro-p-benzoquinone with a secondary amine and formal-dehyde in an organic solvent to obtain 2,6-dimethyl-3-(N,N-disubstituted aminomethyl)-hydro-p-benzoquinone; c) reacting 2,6-dimethyl-3-(N,N-disubstituted aminomethyl)-hydro-p-benzoquinone with hydrogen in the presence of a hydrogenolysis catalyst in an organic solvent to obtain 2,3,5-trimethylhydro-p-benzoquinone; wherein the organic solvent in all steps a), b) and c) is independently selected from the group consisting of methyl tert.-butyl ether, ethyl tert.-butyl ether, methyl tert.-amyl ether, methoxycyclopentane and any mixtures thereof. Preferably the organic solvent used in all steps a), b) and c) is the same.
Public/Granted literature
- US20130211080A1 PROCESS FOR THE MANUFACTURE OF TMHQ Public/Granted day:2013-08-15
Information query