Invention Grant
- Patent Title: Transgenic mouse for screening and for studies of the pharmacodynamics and pharmacokinetics of ligands acting on the oestrogen receptor and its intracellular receptors, and method for the preparation thereof
- Patent Title (中): 用于筛选和用于研究作用于雌激素受体及其细胞内受体的配体的药效学和药代动力学的转基因小鼠及其制备方法
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Application No.: US13076807Application Date: 2011-03-31
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Publication No.: US08809618B2Publication Date: 2014-08-19
- Inventor: Adriana Caterina Maggi , Paolo Ciana
- Applicant: Adriana Caterina Maggi , Paolo Ciana
- Applicant Address: IT Cascina Codazza
- Assignee: T.O.P. (Transgenic Operative Products) S.R.L.
- Current Assignee: T.O.P. (Transgenic Operative Products) S.R.L.
- Current Assignee Address: IT Cascina Codazza
- Agency: Jacobson Holman, PLLC.
- Priority: ITMI00A1503 20000704
- Main IPC: G01N33/00
- IPC: G01N33/00 ; A01K67/027 ; A01N63/00 ; C12N15/00 ; C12N15/63 ; C12N15/79 ; C12N15/85
Abstract:
The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of any intracellular receptor, utilizing a reporter gene inducible by natural or synthetic molecules which modulate the activity of such receptor. The mammal is question is preferably a mouse.
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