Methods, systems and devices for estimating a parameter of interest from a gamma ray spectrum relating to a volume of matter using standard gamma ray spectra from reference samples, wherein there is at least one non-elemental characteristic that is different between the volume and at least one of the reference samples, wherein the non-elemental characteristic difference affects gamma ray interactions. Methods may include deconvolving a gamma ray spectrum obtained from the analysis volume into a plurality of elemental spectral yields, wherein deconvolution includes compensating for effects of the non-elemental characteristic difference. Methods may include using at least one compensation standard spectrum configured to compensate for the effects of the non-elemental characteristic of the at least one of the reference samples.