A dental device with an integrated sanitation chamber is configured for receiving and sanitizing a dental-device accessory, such as a brush, flosser, pic or other dental accessory within a housing of the device. The sanitation chamber is configured to sanitize the dental accessory using one or a combination of ultraviolet light and/or sound waves. The sanitation chamber may form a portion of the device handle to extend it and provide an enlarged handle for improved gripping.