A low voltage isolation circuit is coupled between an input terminal for receiving a high voltage signal and an output terminal for transmitting the high voltage signal to a load. The isolation circuit includes a driving block; having a first driving transistor coupled between a first voltage reference and an intermediate node and a second driving transistor coupled between the intermediate node and a second voltage reference; an isolation block connected between the input and output terminals and, through a protection block to the intermediate node. The protection block includes first and second protection transistors (MD1, coupled in anti-series to each other and having control terminals receiving complementary protection driving signals. The isolation block includes a voltage limiter block, a diode block and a control transistor connected across the diode block between the input and output terminals and having a control terminal connected to the intermediate node through the protection block.