Systems, methods, and apparatus are described that employ a partial interference alignment scheme in conjunction with an interference detection scheme to mitigate interference in quasi-static multiple input multiple output (MIMO) channels. In an aspect, sets of transmitter and receiver pairs are determined based on feasibility of alignment of the transmitters at the receivers of the sets in accordance with an interference alignment scheme and path loss associated with signal transmissions between the transmitter and receiver pairs, wherein the sets include different alignment assignments of the respective transmitters at the respective receivers of the sets. The alignment assignments can include different numbers of the transmitters aligned at the receivers of the sets. A set is then selected from the sets that contributes to an interference profile at the receivers that facilitates interference detection at the receivers. Interference detection at a receiver is further simplified using semi-definite relaxation techniques.