Transmitter-based techniques are provided for compensation of intersymbol interference and/or simultaneous switching outputs, using selective pulse width modulation. One or more signals are transmitted by detecting whether one or more of said signals satisfy one or more predefined signal corruption conditions, wherein said predefined signal corruption conditions indicate that one or more of said signals are anticipated to exhibit one or more of intersymbol interference and simultaneous switching outputs; and selecting a delay for one or more of the signals based on the one or more predefined signal corruptions conditions. The predefined signal corruption conditions comprise, for example, (i) digital data encoded in the one or more signals maintaining a same binary value for two or more consecutive clock cycles (to indicate intersymbol interference); and (ii) a predefined minimum number of aggressor data edges in digital data encoded in the one or more signals, and a corresponding predefined number of victim data edges in the digital data encoded in the one or more signals, wherein the victim edges are moving in an opposite direction to the aggressor data edges (to indicate simultaneous switching outputs).