A controllable multiple-channel chemical transport bus routes and transports fluids, gasses, aerosols, slurries and the like within a larger system. The system and methods are applicable for use in Lab-on-a-Chip (LoC) technology, and can be useful in the implementation of reconfigurable LoC devices. Routes through the bus are determined by control signals and/or sequences of control signals issued under algorithmic control. Several independent flows may occur simultaneously. Adaptations of Clos, Banyan, and other related multi-stage switching architectures in the flow topology can be supported. Sensors are placed at various locations along bus path segments. Information gathered by the sensors can be used for one or more of controlling measured flows, clearing operations, cleaning operations, and control of the timing flow transport. The sensors can be of one or more types such as presence sensors, flow sensors, pressure sensors, temperature sensors, conductivity sensors, optical sensors, ion sensors, and affinity sensors.