Provided is a method of a multi-node cooperation considering a delay in a wireless communication system. A frame format may perform scheduling so that uplink cooperation terminals having a similar delay attribute may be classified into an uplink cooperation zone, to thereby prevent interference between the uplink cooperation zone and a non-cooperation zone. An extended cyclic prefix may be applied according to a delay attribute occurring due to an application of the multi-node cooperation. A cooperation base station of an uplink and a downlink may be determined based on the extended cyclic prefix.