Invention Grant
- Patent Title: Fluorescent imaging agents
- Patent Title (中): 荧光成像剂
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Application No.: US12355777Application Date: 2009-01-17
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Publication No.: US08815214B2Publication Date: 2014-08-26
- Inventor: Milind Rajopadhye , Kevin Groves , Dorin V. Preda
- Applicant: Milind Rajopadhye , Kevin Groves , Dorin V. Preda
- Applicant Address: US MA Waltham
- Assignee: VisEn Medical, Inc.
- Current Assignee: VisEn Medical, Inc.
- Current Assignee Address: US MA Waltham
- Agency: Goodwin Procter LLP
- Main IPC: A61B5/00
- IPC: A61B5/00 ; A61B8/00 ; A61B10/00 ; A61K38/12 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; A61K38/00 ; A61K38/04

Abstract:
Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
Public/Granted literature
- US20090220430A1 Fluorescent Imaging Agents Public/Granted day:2009-09-03
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