Invention Grant
- Patent Title: Aglycosylated immunoglobulin mutants
- Patent Title (中): 糖基化免疫球蛋白突变体
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Application No.: US12746411Application Date: 2008-12-05
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Publication No.: US08815237B2Publication Date: 2014-08-26
- Inventor: K. Dane Wittrup , Jeffrey Ravetch , Stephen Lael Sazinsky
- Applicant: K. Dane Wittrup , Jeffrey Ravetch , Stephen Lael Sazinsky
- Applicant Address: US MA Cambridge US NY New York
- Assignee: Massachusetts Institute of Technology,The Rockefeller University
- Current Assignee: Massachusetts Institute of Technology,The Rockefeller University
- Current Assignee Address: US MA Cambridge US NY New York
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- International Application: PCT/US2008/085757 WO 20081205
- International Announcement: WO2009/079242 WO 20090625
- Main IPC: A61K39/395
- IPC: A61K39/395
Abstract:
The present invention is based, in part, on our discovery of immunoglobulins (e.g., immunoglobulin G (IgG)) polypeptides (e.g., murine or human IgG, such as human IgG1) that are aglycosylated yet retain the ability to bind to an Fc receptor, such as an activating Fc receptor (e.g., FcγRIIA and/or FcγRIIIA).
Public/Granted literature
- US20110059075A1 AGLYCOSYLATED IMMUNOGLOBULIN MUTANTS Public/Granted day:2011-03-10
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