Invention Grant
- Patent Title: Induction of tumor immunity by variants of folate binding protein
- Patent Title (中): 通过叶酸结合蛋白的变体诱导肿瘤免疫
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Application No.: US13556876Application Date: 2012-07-24
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Publication No.: US08815256B2Publication Date: 2014-08-26
- Inventor: Constantin G. Ioannides , George E. Peoples
- Applicant: Constantin G. Ioannides , George E. Peoples , Kathleen G. Peoples
- Applicant Address: US MD Bethesda
- Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Current Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- Current Assignee Address: US MD Bethesda
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Cynthia L. Kanik
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K14/47
Abstract:
The present invention is directed to variants of antigens comprising folate binding protein epitopes as a composition associated with providing immunity against a tumor in an individual. The variant is effective in inducing cytotoxic T-lymphocytes but preferably not to the extent that they become sensitive to silencing by elimination, such as by apoptosis, or by anergy, as in unresponsiveness.
Public/Granted literature
- US20130039935A1 INDUCTION OF TUMOR IMMUNITY BY VARIANTS OF FOLATE BINDING PROTEIN Public/Granted day:2013-02-14
Information query
