Invention Grant
US08815261B2 Composition for external application comprising aripiprazole and organic acid as active ingredients
有权
用于外用的组合物,其包含阿立哌唑和有机酸作为活性成分
- Patent Title: Composition for external application comprising aripiprazole and organic acid as active ingredients
- Patent Title (中): 用于外用的组合物,其包含阿立哌唑和有机酸作为活性成分
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Application No.: US13378615Application Date: 2010-06-17
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Publication No.: US08815261B2Publication Date: 2014-08-26
- Inventor: Noritaka Hanma
- Applicant: Noritaka Hanma
- Applicant Address: JP Higashikagawa
- Assignee: MEDRx Co., Ltd.
- Current Assignee: MEDRx Co., Ltd.
- Current Assignee Address: JP Higashikagawa
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JP2009-146414 20090619
- International Application: PCT/JP2010/004066 WO 20100617
- International Announcement: WO2010/146872 WO 20101223
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61F13/00 ; A61K9/70 ; A61K38/00 ; A61P25/18 ; A01N43/42 ; A61K31/47 ; A61K31/496 ; A61K47/12

Abstract:
[Summary] An external preparation formulation superior in the transdermal absorbability has been desired as a new administration route of aripiprazole. Transdermal absorption of aripiprazole has been enabled for the first time by appropriately combining aripiprazole and an organic acid (particularly fatty acid with low lipophilicity). That is, it has been found that more superior transdermal absorbability can be achieved by forming a salt by using a compound showing lipophilicity within the range of −1.5-2, such as fatty acid and the like. It has been further found that the transdermal absorbability is remarkable improved by appropriately selecting the solvent composition. As a result, since a new dosage form of aripiprazole other than oral preparation has been developed, a new transdermal absorption preparation of aripiprazole can be provided.
Public/Granted literature
- US20120184563A1 COMPOSITION FOR EXTERNAL APPLICATION COMPRISING ARIPIPRAZOLE AND ORGANIC ACID AS ACTIVE INGREDIENTS Public/Granted day:2012-07-19
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