Invention Grant
US08815503B2 Compositions and methods for immunostimulatory RNA oligonucleotides
有权
免疫刺激RNA寡核苷酸的组成和方法
- Patent Title: Compositions and methods for immunostimulatory RNA oligonucleotides
- Patent Title (中): 免疫刺激RNA寡核苷酸的组成和方法
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Application No.: US12066906Application Date: 2006-09-14
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Publication No.: US08815503B2Publication Date: 2014-08-26
- Inventor: Gunther Hartmann , Veit Hornung
- Applicant: Gunther Hartmann , Veit Hornung
- Applicant Address: DE Bonn
- Assignee: Rheinische Friedrich-Wilhelms-Universitat Bonn
- Current Assignee: Rheinische Friedrich-Wilhelms-Universitat Bonn
- Current Assignee Address: DE Bonn
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: EP05020019 20050914
- International Application: PCT/EP2006/008972 WO 20060914
- International Announcement: WO2007/031319 WO 20070322
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; A61K39/39 ; C07H21/02 ; C07H21/04 ; A61K38/20
Abstract:
The present invention provides 4-nucleotide (4mer) RNA motifs that confer immunostimulatory activity, in particular, IL-12-inducing activity to a single-stranded RNA oligonucleotide. The present invention also provides single-stranded RNA oligonucleotides, including antisense RNA, with high or low immunostimulatory activity. The present invention further provides the use of the RNA oligonucleotides of the invention for therapeutic purposes.
Public/Granted literature
- US20090111765A1 COMPOSITIONS AND METHODS FOR IMMUNOSTIMULATORY RNA OLIGONUCLEOTIDES Public/Granted day:2009-04-30
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