Invention Grant
US08815527B2 Methods and compositions for detecting the activation state of multiple proteins in single cells
有权
用于检测单细胞中多种蛋白质的活化状态的方法和组合物
- Patent Title: Methods and compositions for detecting the activation state of multiple proteins in single cells
- Patent Title (中): 用于检测单细胞中多种蛋白质的活化状态的方法和组合物
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Application No.: US13094737Application Date: 2011-04-26
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Publication No.: US08815527B2Publication Date: 2014-08-26
- Inventor: Omar D. Perez , Garry P. Nolan
- Applicant: Omar D. Perez , Garry P. Nolan
- Applicant Address: US CA Palo Alto
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Palo Alto
- Agency: Bozicevic, Field & Francis LLP
- Agent Bret E. Field
- Main IPC: G01N33/00
- IPC: G01N33/00 ; G01N21/64 ; G01N21/76 ; G01N33/50 ; G01N33/58 ; C12Q1/48 ; G01N33/543 ; G01N33/573 ; G01N33/53
Abstract:
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
Public/Granted literature
- US20130177970A1 METHODS AND COMPOSITIONS FOR DETECTING THE ACTIVATION STATE OF MULTIPLE PROTEINS IN SINGLE CELLS Public/Granted day:2013-07-11
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