Invention Grant
US08815543B2 Methods of producing antigen-specific B cell populations in the presence of CD40:CD40L, BAFF:BAFF receptor and Fas:FasL stimulation
有权
在CD40存在下产生抗原特异性B细胞群的方法：CD40L，BAFF：BAFF受体和Fas：FasL刺激
- Patent Title: Methods of producing antigen-specific B cell populations in the presence of CD40:CD40L, BAFF:BAFF receptor and Fas:FasL stimulation
- Patent Title (中): 在CD40存在下产生抗原特异性B细胞群的方法：CD40L，BAFF：BAFF受体和Fas：FasL刺激
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Application No.: US13504111Application Date: 2010-10-25
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Publication No.: US08815543B2Publication Date: 2014-08-26
- Inventor: Daisuke Kitamura , Takuya Nojima
- Applicant: Daisuke Kitamura , Takuya Nojima
- Assignee: Tokyo University of Science Educational Foundation Administrative Organization
- Current Assignee: Tokyo University of Science Educational Foundation Administrative Organization
- Agency: Marshall, Gerstein & Borun LLP
- Priority: JP2009-251362 20091030
- International Application: PCT/JP2010/068868 WO 20101025
- International Announcement: WO2011/052545 WO 20110505
- Main IPC: C12N5/00
- IPC: C12N5/00
Abstract:
The present invention provides a method for producing an antigen-specific B cell population comprising IgG-positive B cells specific to a specific antigen, the method comprising: culturing IgG-positive B cells together with the specific antigen in the presence of IL-21, while conferring stimulation to the IgG-positive B cells via CD40, a BAFF receptor and Fas; and screening for antigen-specific B cells specific to the specific antigen to obtain an antigen-specific B cell population comprising the IgG-positive B cells specific to the specific antigen.
Public/Granted literature
- US20120214192A1 Method for Producing Antigen-specific B Cell Population Public/Granted day:2012-08-23
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