Invention Grant
- Patent Title: Phagocytic cell delivery of RNAI
- Patent Title (中): 吞噬细胞RNAI的传递
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Application No.: US13054696Application Date: 2009-07-17
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Publication No.: US08815818B2Publication Date: 2014-08-26
- Inventor: Dmitry Samarsky , Tod M. Woolf
- Applicant: Dmitry Samarsky , Tod M. Woolf
- Applicant Address: US MA Marlborough
- Assignee: RXi Pharmaceuticals Corporation
- Current Assignee: RXi Pharmaceuticals Corporation
- Current Assignee Address: US MA Marlborough
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2009/004144 WO 20090717
- International Announcement: WO2010/008582 WO 20100121
- Main IPC: C12N15/11
- IPC: C12N15/11
Abstract:
The present invention provides a particulate delivery system for delivering an RNAi construct to phagocytic cells such as macrophages, comprising various configurations of a complex comprising a phagocytic cell-targeting moiety and an RNAi construct. The invention further provides methods of making the delivery system, and their uses, such as treating phagocytic cell-associated disease conditions.
Public/Granted literature
- US20120016005A1 PHAGOCYTIC CELL DELIVERY OF RNAI Public/Granted day:2012-01-19
Information query
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