Invention Grant
US08815829B2 3′-azido purine nucleotide prodrugs for treatment of viral infections
有权
3'-叠氮嘌呤核苷酸前药用于治疗病毒感染
- Patent Title: 3′-azido purine nucleotide prodrugs for treatment of viral infections
- Patent Title (中): 3'-叠氮嘌呤核苷酸前药用于治疗病毒感染
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Application No.: US13132920Application Date: 2009-12-09
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Publication No.: US08815829B2Publication Date: 2014-08-26
- Inventor: Raymond F. Schinazi , John W. Mellors , Nicolas Paul Sluis-Cremer , Steven J. Coats , Richard Anthony Whitaker , Brian David Herman , Jong Hyun Cho , Longhu Zhou , Hongwang Zhang
- Applicant: Raymond F. Schinazi , John W. Mellors , Nicolas Paul Sluis-Cremer , Steven J. Coats , Richard Anthony Whitaker , Brian David Herman , Jong Hyun Cho , Longhu Zhou , Hongwang Zhang
- Applicant Address: US GA Tucker US GA Altanta US PA Pittsburgh
- Assignee: RFS Pharma, LLC,Emory University,University of Pittsburgh—of the Commonwealth System of Higher Education
- Current Assignee: RFS Pharma, LLC,Emory University,University of Pittsburgh—of the Commonwealth System of Higher Education
- Current Assignee Address: US GA Tucker US GA Altanta US PA Pittsburgh
- Agency: Hultquist, PLLC
- Agent David Bradin
- International Application: PCT/US2009/067400 WO 20091209
- International Announcement: WO2010/068708 WO 20100617
- Main IPC: C07H19/04
- IPC: C07H19/04 ; A61K31/70 ; C07H19/20 ; C07D473/16 ; C07H19/173 ; C07D473/18 ; C07H19/207 ; A61K31/437
Abstract:
The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, and HBV, in human patients or other animal hosts. The compounds are 3′-azido-2′,3′-dideoxy purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1 and HBV.
Public/Granted literature
- US20120135951A1 3'-AZIDO PURINE NUCLEOTIDE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS Public/Granted day:2012-05-31
Information query
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