Invention Grant
- Patent Title: 1,4-Oxazepines as BACE1 and/or BACE2 inhibitors
- Patent Title (中): 作为BACE1和/或BACE2抑制剂的1,4-氧氮杂
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Application No.: US13369322Application Date: 2012-02-09
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Publication No.: US08815841B2Publication Date: 2014-08-26
- Inventor: Hans Hilpert , Robert Narquizian
- Applicant: Hans Hilpert , Robert Narquizian
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Priority: EP11155051 20110218
- Main IPC: A61K31/553
- IPC: A61K31/553
Abstract:
This invention relates to compounds of the formula wherein and R1 to R3 are as described herein, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as pharmaceuticals for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.
Public/Granted literature
- US20130040936A1 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS Public/Granted day:2013-02-14
Information query
IPC分类:
