Invention Grant
US08815845B2 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
有权
1,4-苯并二氮杂-2,5-diones和具有治疗性质的相关化合物
- Patent Title: 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
- Patent Title (中): 1,4-苯并二氮杂-2,5-diones和具有治疗性质的相关化合物
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Application No.: US13508261Application Date: 2010-11-03
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Publication No.: US08815845B2Publication Date: 2014-08-26
- Inventor: Gary D. Glick
- Applicant: Gary D. Glick
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2010/055255 WO 20101103
- International Announcement: WO2011/062766 WO 20110526
- Main IPC: C07D403/10
- IPC: C07D403/10 ; C07D401/10 ; C07D471/04 ; A61K31/437 ; A61P9/10 ; A61P9/12
Abstract:
The present invention provides novel chemical compounds characterized as Rho kinase (ROCK) inhibitors, methods for their discovery, and their therapeutic, research, and diagnostic use. In particular, the present invention provides 1,4-benzodiazepine-2,5-dione compounds and related compounds having ROCK inhibitory activity, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with ROCK activity.
Public/Granted literature
- US20120270862A1 1,4-BENZODIAZEPINE-2,5-DIONES AND RELATED COMPOUNDS WITH THERAPEUTIC PROPERTIES Public/Granted day:2012-10-25
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